mh-nexus.de

There's a tiny command-line tool which can do this: bincmp 2.2 (http://sourceforge.net/projects/bincmp/files/bincmp2/)
For your example, create a text file named "patch.txt" with the following lines:
0004AE: 00 00
0004AF: 00 00
0004B0: 80 40
0004B1: 3F 3F

and execute "bincmp -patch patch.txt ...