HxD Hex Editor.ini won't have the read-only attribute.
However, if you chose the Preserve, then make configuration readonly radio button, the read-only attribute would be set to HxD Hex Editor.ini.
Steps to reproduce:
1. Start HxD v2.0.0.0.
2. Click Tools, then Options....
3. Choose the Discard (= configuration is readonly) radio button.
4. Click OK.
5. Exit HxD v2.0.0.0.
6. Locate HxD Hex Editor.ini in Settings folder.
7. Right-click HxD Hex Editor.ini and click Properties.
8. The read-only checkbox would be unchecked.
When fixing this, note that choosing Preserve clears the read-only attribute if it's been manually set to HxD Hex Editor.ini.
So, for the sake of consistency, choosing Discard (= configuration is readonly) should set the read-only attribute if it's been manually cleared.
In other words, make sure that HxD Hex Editor.ini attributes match the saved configuration every startup/exit.
P.S. If this is not a bug, and something is wrong with my computer (again